ASPR recently updated the Mpox Vaccination Operational Planning Guide to aid state, tribal, local and territorial planning and response efforts. Revisions include updates to future JYNNEOS availability via a threshold approach. This approach covers requests for supplemental product above a threshold, reporting requirements, virus and disease nomenclature, and where relevant any anticipated changes due to the public health emergency (PHE) declaration expiration. Revisions also include updated CDC language regarding intradermal and subcutaneous administration and updates on disposal of expired product.