On May 30, CDC reported that a second human case of highly pathogenic avian influenza (HPAI) A(H5) virus infection has been identified in Michigan. This case is the third human case associated with an ongoing multistate outbreak of A(H5N1) in U.S. dairy cows. However, it is the first human case of H5 in the United States to report more typical symptoms of acute respiratory illness associated with influenza virus infection, including A(H5N1) viruses. The risk to members of the public who do not have exposure to infected animals remains low. CDC continues to closely monitor available data from influenza surveillance systems, particularly in affected states, and there has been no sign of unusual influenza activity in people, including no increase in emergency room visits for influenza and no increase in laboratory detection of human influenza cases.