On the morning of Tuesday, February 7, 2023, a 10-alarm fire broke out at Signature Healthcare Brockton Hospital in an electrical room, causing an almost immediate failure of the hospital’s electrical system. The hospital safely evacuated 162 patients in coordination with the fire department and was subsequently closed for an extended recovery period. This article supports a webinar where three leaders who managed the response highlighted successes and challenges of incident command, communications, preparedness and response plans, and patient evacuation, transfers, and tracking during and after the incident.