The Healthcare and Public Health Sector Coordinating Council (HSCC) Cybersecurity Working Group developed the Playbook for AI Clinical Resilience to help healthcare organizations detect, analyze, and respond to threats affecting AI-integrated clinical operations. The guide provides a framework for identifying AI touchpoints, assessing threats, and developing playbooks tailored to inpatient, acute care, and outpatient workflows. It addresses risks such as model drift, triage misclassification, system downtime, and privacy vulnerabilities in AI-enabled communication tools. The intended audience includes clinical teams, governance leaders, technical experts, and compliance officers. The framework supports patient safety, data integrity, regulatory compliance, and operational resilience. For additional information, review the HSCC Playbook for AI Clinical Resilience.