The Multi-State Information Sharing and Analysis Center (MS-ISAC) released a cybersecurity advisory regarding multiple critical vulnerabilities discovered in Microsoft products. The most severe of these vulnerabilities could allow attackers to execute remote code in the context of a logged-in user, potentially granting them the ability to install programs, view, alter, or delete data, and create new accounts with full administrative rights. Systems with administrative privileges are at higher risk, while those with more limited user rights may be less affected. Although there are currently no known exploits in the wild, the advisory outlines a broad list of affected Microsoft products, including Visual Studio, Windows Kernel, Microsoft Office applications, Azure services, and more. MS-ISAC recommends that organizations apply the necessary patches immediately after testing, implement robust vulnerability management processes, and apply the Principle of Least Privilege to minimize the impact of any successful attacks. The advisory also emphasizes the importance of user training to recognize social engineering threats and the use of host-based intrusion detection and prevention systems. For additional information, refer to the Microsoft April Security Update and the MS-ISAC advisory.