Since January 1, 2023, the Democratic Republic of the Congo (DRC) has reported 12,569 suspected mpox cases and 581 deaths, largely attributed to clade I. The current threat for clade I monkeypox virus (MPXV) in travelers to the U.S. is low, however, clinicians should be aware of the possibility of clade I MPXV in travelers who have been in DRC.
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