In 2022, during the pediatric surge caused by respiratory syncytial virus (RSV), ASPR’s Regional Disaster Health Response System (RDHRS) demonstration sites provided critical support for hospitals and clinicians, working to enhance situational awareness within their regions by standing up patient tracking dashboards, developing and disseminating pediatric surge tools and resources, and hosting meetings with all response partners to provide technical assistance and real-time updates on regional surge status. By leveraging their robust partner networks, the RDHRS sites increased bidirectional communication between all entities and organizations involved in pediatric surge response, supporting a well-informed and organized system that prioritized timely and effective patient care.