The Incident Response Guide: Special Pathogens provides a structured approach for health care facilities to respond to special pathogen events, including suspected or confirmed high-consequence infectious diseases (HCIDs). It supports hospitals and health care coalitions in implementing a coordinated emergency response while ensuring patient and staff safety. This guide includes incident command activation, patient identification and isolation, personal protective equipment guidelines, waste management, security measures, and patient transfers. The guide helps promote best practices in hospital response and recovery.